Thursday, Mar.28, 2024
miRNA:

hsa-miR-127

Disease:

bladder cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

BCL6

Validated targets of miRNA from TarBase:

BCL6,Rtl1/Peg11 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

miR-127 is usually expressed as part of a miRNA cluster in normal cells but not in cancer cells, suggesting that it is subject to epigenetic silencing. In addition, the proto-oncogene BCL6, a potential target of miR-127, was translationally downregulated. These results suggest that DNA demethylation and histone deacetylase inhibition can activate expression of miRNAs that may act as tumor suppressors.

 

 

Reference:

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. | PMID:16766263
Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, Jones PA.
Cancer Cell. 2006 Jun;9(6):435-43.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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