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Thursday, May.2, 2024
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miRNA: |
hsa-miR-127 |
Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
BCL6 |
Validated targets of miRNA from TarBase: |
BCL6,Rtl1/Peg11 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-127 is usually expressed as part of a miRNA cluster in normal cells but not in cancer cells, suggesting that it is subject to epigenetic silencing. In addition, the proto-oncogene BCL6, a potential target of miR-127, was translationally downregulated. These results suggest that DNA demethylation and histone deacetylase inhibition can activate expression of miRNAs that may act as tumor suppressors. |
Reference:
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. | PMID:16766263
Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, Jones PA.
Cancer Cell. 2006 Jun;9(6):435-43. |
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