| miRNA: |
hsa-miR-127 |
| Disease: |
cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
BCL6 |
Validated targets of miRNA from TarBase: |
BCL6,Rtl1/Peg11 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Be methylated in tumor cells. miR-127 is located on chromosome 14q32, a region that is involved in several types of translocations in hematological malignancies and deleted by LOH in solid tumors. |
Reference:
CpG island hypermethylation of tumor suppressor microRNAs in human cancer. | PMID:17581274
Lujambio A, Esteller M.
Cell Cycle. 2007 Jun 15;6(12):1455-9. Epub 2007 May 4. |
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