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Saturday, May.18, 2024
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| miRNA: |
hsa-miR-1 |
| Disease: |
cardiomyopathy |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
HSP60,HSP70 |
Validated targets of miRNA from TarBase: |
GJA1,Hand2,HDAC4,TMSB4X : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-1 and miR-133 are involved in regulating cell fate with increased miR-1 and/or decreased miR-133
levels favoring apoptosis and decreased miR-1 and/or miR-133 levels favoring survival. Post-transcriptional repression of HSP60 and HSP70 by miR-1 and of caspase-9 by miR-133 contributes significantly to their opposing actions.
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Reference:
The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. | PMID:17715156
Xu C, Lu Y, Pan Z, Chu W, Luo X, Lin H, Xiao J, Shan H, Wang Z, Yang B.
J Cell Sci. 2007 Sep 1;120(Pt 17):3045-52. |
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