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Tuesday, May.7, 2024
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| miRNA: |
hsa-miR-16 |
| Disease: |
chronic lymphocytic leukemia (CLL) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
RARS |
Validated targets of miRNA from TarBase: |
BCL2,CGI-38 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-15 and miR-16 are located at chromosome 13q14, a region deleted in more than half of B cell chronic lymphocytic leukemia (CLL)s (B-CLL). Detailed deletion and expression analysis shows that miR-15 and miR-16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (68%) of CLL cases. |
Reference:
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. | PMID:12434020
Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM.
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9. Epub 2002 Nov 14. |
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