hsa-miR-181b

chronic lymphocytic leukemia (CLL)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

Tcl1

Validated targets of miRNA from TarBase:

unknown : More...

Description:

miR-29b and miR-181b target oncogene TCL1, which leads to malignant cell proliferation.

Reference:

Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. | PMID:17178851
Pekarsky Y, Santanam U, Cimmino A, Palamarchuk A, Efanov A, Maximov V, Volinia S, Alder H, Liu CG, Rassenti L, Calin GA, Hagan JP, Kipps T, Croce CM.
Cancer Res. 2006 Dec 15;66(24):11590-3.