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Friday, Apr.19, 2024
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| miRNA: |
hsa-miR-181c |
| Disease: |
hepatocellular carcinoma (HCC) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
microarray |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: One of the miRNAs differentially expressed between human HCC and LC.To validate their ability to correctly distinguish HCC or cirrhosis tissue types, the 35 deregulated miRNAs were assayed using the algorithms SVM and PAM. PAM correctly classified 86% of the samples and SVM classified 91%. |
Reference:
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. | PMID:17616664
Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, Calin GA, Giovannini C, Ferrazzi E, Grazi GL, Croce CM, Bolondi L, Negrini M.
Cancer Res. 2007 Jul 1;67(13):6092-9. |
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