Friday, Mar.29, 2024
miRNA:

hsa-miR-132

Disease:

Huntington's disease (HD)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

p250GAP

Validated targets of miRNA from TarBase:

RICS/p250GAP : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

increased levels of nuclear REST in HD leads to both a direct repression of REST target genes such as BDNF and to an indirect activation of gene expression by increased repression of miRNAexpression The latter is exemplified by loss of miR-132, in turn leading to higher levels of p250GAP mRNA.

 

 

Reference:

A microRNA-based gene dysregulation pathway in Huntington's disease. | PMID:18082412
Johnson R, Zuccato C, Belyaev ND, Guest DJ, Cattaneo E, Buckley NJ.
Neurobiol Dis. 2008 Mar;29(3):438-45. Epub 2007 Nov 13.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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