miRNA: |
hsa-miR-132 |
Disease: |
Huntington's disease (HD) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
p250GAP |
Validated targets of miRNA from TarBase: |
RICS/p250GAP : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: increased levels of nuclear REST in HD leads to both a direct repression of REST target genes such as BDNF and to an indirect activation of gene expression by increased repression of miRNAexpression The latter is exemplified by loss of miR-132, in turn leading to higher levels of p250GAP mRNA. |
Reference:
A microRNA-based gene dysregulation pathway in Huntington's disease. | PMID:18082412
Johnson R, Zuccato C, Belyaev ND, Guest DJ, Cattaneo E, Buckley NJ.
Neurobiol Dis. 2008 Mar;29(3):438-45. Epub 2007 Nov 13. |
|
|