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Friday, Apr.19, 2024
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| miRNA: |
hsa-miR-141 |
| Disease: |
cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
ZEB1 |
Validated targets of miRNA from TarBase: |
Clock : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The embryonic programme 'epithelial–mesenchymal transition'(EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc-finger E-box binding homeobox 1(ZEB1) is a crucial inducer of EMT in various human tumours, and was recently shown to promote invasion and metastasis of tumour cells. ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c. Notably, the EMT activators transforming growth factor b2 and ZEB1 are the
predominant targets downregulated by these microRNAs. |
Reference:
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. | PMID:18483486
Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, Brabletz T.
EMBO Rep. 2008 Jun;9(6):582-9. Epub 2008 May 16. |
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