| miRNA: |
hsa-miR-143 |
| Disease: |
chronic lymphocytic leukemia (CLL) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
ERK5 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Expression levels of miR-143 and -145 were significantly decreased in B-cell malignancies.Transfection of RAJI cells with precursor or mature miR-143 or -145, respectively, causes growth inhibition. |
Reference:
Downregulation of microRNAs-143 and -145 in B-cell malignancies. | PMID:17892514
Akao Y, Nakagawa Y, Kitade Y, Kinoshita T, Naoe T.
Cancer Sci. 2007 Dec;98(12):1914-20. Epub 2007 Sep 24. |
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