| miRNA: |
hsa-miR-143 |
| Disease: |
colorectal cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
ERK5 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-143 and miR-145 expression levels were extremely reduced in the colon cancer cells. The transfection of each precursor miRNA into the cells demonstrated a significant growth inhibition in human colon cancer DLD-1 and SW480 cells. |
Reference:
MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers. | PMID:16969504
Akao Y, Nakagawa Y, Naoe T.
Oncol Rep. 2006 Oct;16(4):845-50. |
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