Friday, Mar.29, 2024
miRNA:

hsa-miR-143

Disease:

Obesity

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

ERK5

Validated targets of miRNA from TarBase:

unknown : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

miR-143 was involved in adipocyte differentiation, regulating fat metabolism. Inhibition of miR-143 effectively inhibited adipocyte differentiation. In addition, protein levels of the proposed miR-143 target ERK5 were higher in ASO-treated adipocytes.

 

 

Reference:

MicroRNA-143 regulates adipocyte differentiation. | PMID:15504739
Esau C, Kang X, Peralta E, Hanson E, Marcusson EG, Ravichandran LV, Sun Y, Koo S, Perera RJ, Jain R, Dean NM, Freier SM, Bennett CF, Lollo B, Griffey R.
J Biol Chem. 2004 Dec 10;279(50):52361-5. Epub 2004 Oct 25.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
Please don't hesitate to address comments/questions/suggestions regarding this webpage to: ydwang@hit.edu.cn or yunliu@iu.edu