| miRNA: |
hsa-miR-145 |
| Disease: |
colorectal cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
IRS-1 |
Validated targets of miRNA from TarBase: |
FLJ21308 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-145 targets the 3 -UTR of IRS-1 mRNA, and that the targeting has a profound effect on the growth of human colon cancer cells. This is the first demonstration of a specific miR targeting a transduction molecule of the IGF-IR/insulin receptor signaling pathway. Its inhibition of growth in human cancer cells in culture is compatible with the well known ability of IRS-1 to stimulate
cell proliferation and transformation. |
Reference:
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. | PMID:17827156
Shi B, Sepp-Lorenzino L, Prisco M, Linsley P, deAngelis T, Baserga R.
J Biol Chem. 2007 Nov 9;282(45):32582-90. Epub 2007 Sep 7. |
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