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Tuesday, May.14, 2024
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| miRNA: |
hsa-miR-199a |
| Disease: |
cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The expression of miR-199a/a* is silenced in all proliferating cell lines tested except fibroblasts. Introduction of miR-199a/a* caused apoptosis in cancer cells. |
Reference:
MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2). | PMID:18456660
Kim S, Lee UJ, Kim MN, Lee EJ, Kim JY, Lee MY, Choung S, Kim YJ, Choi YC.
J Biol Chem. 2008 Jun 27;283(26):18158-66. Epub 2008 May 2. |
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