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Thursday, May.9, 2024
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| miRNA: |
hsa-miR-199a |
| Disease: |
epithelial ovarian cancer (EOC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
IKK-beta |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Using EOC cellsisolated from malignant ovarian cancer ascites and solid tumors,The authors identified IKK-beta as a major factor promoting a functional TLR–MyD88–NF-k-beta pathway that confers to EOC cell the capacity to constitutively secrete proinflammatory/ protumor cytokines and therefore promoting tumor progression and chemoresistance.Furthermore, they describe for the first time the identification of the microRNA hsa-miR-199a as a regulator of IKK-beta expression. |
Reference:
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. | PMID:18408758
Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, Visintin I, Leiser A, Schwartz PE, Rutherford T, Mor G.
Oncogene. 2008 Aug 7;27(34):4712-23. Epub 2008 Apr 14. |
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