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Friday, Apr.19, 2024
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| miRNA: |
hsa-let-7c |
| Disease: |
uterine leiomyoma (ULM) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
HMGA2 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: One of the top five up-regulated miRNAs in Uterine Leiomyomas (ULMs).Overexpression of the let-7
miRNAs is significant in more than two-thirds of the ULMs examined. The cause of let-7 overexpression in ULMs is unclear. Let-7 miRNAs may affect the tumorigenesis of ULMs in several aspects. First, overexpression of let-7 miRNAs in ULMs may play a role in promoting terminal differentiation of these smooth muscle tumors as we see in embryonic development. Second, given that ULMs are benign and rarely progress to malignancy, a high level of let-7 miRNAs in ULMs may be the
protective factors preventing overexpression of their targeting oncogenes, such as RAS and MYC. |
Reference:
A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas. | PMID:17243163
Wang T, Zhang X, Obijuru L, Laser J, Aris V, Lee P, Mittal K, Soteropoulos P, Wei JJ.
Genes Chromosomes Cancer. 2007 Apr;46(4):336-47. |
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