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Thursday, May.2, 2024
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| miRNA: |
hsa-let-7d |
| Disease: |
lung cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
CDK6, CDC25A |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Overexpression of let-7 in lung cancer cell lines alters cell cycle progression and reduces cell division.multiple genes involved in cell cycle and cell division functions are also directly or indirectly repressed by let-7. |
Reference:
The let-7 microRNA represses cell proliferation pathways in human cells. | PMID:17699775
Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D, Slack FJ.
Cancer Res. 2007 Aug 15;67(16):7713-22. |
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