Thursday, Mar.28, 2024
miRNA:

hsa-miR-19a

Disease:

Cowden Syndrome

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

PTEN

Validated targets of miRNA from TarBase:

PTEN : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Differential expression of PTEN-targeting miR-19a and miR-21 modulates the PTEN protein levels and the CS phenotype, irrespective of the patient’s mutation status, and support their roles as genetic modifiers in CS.

 

 

Reference:

Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome. | PMID:18460397
Pezzolesi MG, Platzer P, Waite KA, Eng C.
Am J Hum Genet. 2008 May;82(5):1141-9.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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