miRNA: |
hsa-miR-19a |
Disease: |
Cowden Syndrome |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
PTEN |
Validated targets of miRNA from TarBase: |
PTEN : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Differential expression of PTEN-targeting miR-19a and miR-21 modulates the PTEN protein levels and the CS phenotype, irrespective of the patient’s mutation status, and support their roles
as genetic modifiers in CS. |
Reference:
Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome. | PMID:18460397
Pezzolesi MG, Platzer P, Waite KA, Eng C.
Am J Hum Genet. 2008 May;82(5):1141-9. |
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