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Wednesday, Apr.24, 2024
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| miRNA: |
hsa-let-7d |
| Disease: |
ovarian cancer (OC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
HMGA2 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Ovarian cancer (OC) patients with high HMGA2 and low let-7 expression in their cancer cells had a lower survival than patients with a low HMGA2/high let-7 ratio. HMGA2 upregulation occurs early during OC progression before the tumors begin to metastasize both in human patients and in an OC mouse model.HMGA2 is a more sensitive target of let-7 than RAS. |
Reference:
Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. | PMID:17957144
Park SM, Shell S, Radjabi AR, Schickel R, Feig C, Boyerinas B, Dinulescu DM, Lengyel E, Peter ME.
Cell Cycle. 2007 Aug;6(21):2585-90. Epub 2007 Aug 6. |
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