Description: The authors conclude that, in addition to miR-106a, miR-20b, miR-19b-2, and miR-92-2 overexpression in tumors, their capacity to induce anchorage independence growth strongly supports an oncogenic
potential for those miRNAs. they also conclude that Mylip and Rbp1-like are true targets of the miR-106-363 cluster(miR-106a, miR-18b, miR-20b, miR-19b-2, miR-92-2, and miR-363). More specifically, Rbp1-like seemed only targeted by miR-106a/miR-20b, whereas Mylip could be targeted by the four miRNAs(miR-106a, miR-20b, miR-19b-2, and miR-92-2) with miR-106a/miR-20b being more efficient. |