| miRNA: |
hsa-miR-203 |
| Disease: |
skin disease |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
p63 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-203 is induced in the skin concomitantly with stratification and differentiation. By altering miR-203's spatiotemporal expression in vivo, the authors show that miR-203 promotes epidermal differentiation by restricting proliferative potential and inducing cell-cycle exit. P63 is one of the conserved targets of miR-203 across vertebrates. Notably, p63 is an essential regulator of stem-cell maintenance in stratified epithelial tissues. The authors show that miR-203 directly represses the expression of p63: it fails to switch off suprabasally when either Dicer1 or miR-203 is absent and it becomes repressed basally when miR-203 is prematurely expressed. |
Reference:
A skin microRNA promotes differentiation by repressing 'stemness'. | PMID:18311128
Yi R, Poy MN, Stoffel M, Fuchs E.
Nature. 2008 Mar 13;452(7184):225-9. Epub 2008 Mar 2. |
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