hsa-miR-155

pancreatic cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

TP53INP1

Validated targets of miRNA from TarBase:

AGTR1 : More...

Description:

The expression of TP53INP1, which presents anti-tumoral activity, is repressed by the oncogenic miR-155.

Reference:

Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. | PMID:17911264
Gironella M, Seux M, Xie MJ, Cano C, Tomasini R, Gommeaux J, Garcia S, Nowak J, Yeung ML, Jeang KT, Chaix A, Fazli L, Motoo Y, Wang Q, Rocchi P, Russo A, Gleave M, Dagorn JC, Iovanna JL, Carrier A, Pebusque MJ, Dusetti NJ.
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16170-5. Epub 2007 Oct 2.